- Generic Name: Dapoxetine
- Brand Name: Poxet
- Dosage (mg): 30/60/90
- Active Component: Dapoxetine
- Drug Class: Selective Serotonin Reuptake Inhibitors (SSRIs)
- Minimal Price: $0.99
- Shipping: Worldwide
Priligy (active substance is dapoxetine) is created specifically for those who have problems with premature ejaculation. This is an effective remedy that helps prolong the sexual intercourse and bring maximum pleasure to a partner. Thanks to this drug, a man no longer has to hear the disappointed sigh of his beloved and blush heading into the shower at the very beginning of sexual intercourse. In today’s world, about 30% of male population suffer from the problem of premature ejaculation. Even erectile disorder that affects about 15% of all men on the planet, by its prevalence, remains far behind premature ejaculation. This ratio of the damaging effect of these two men’s problems is mainly due to the fact that elderly men suffer from erectile dysfunction, whereas premature ejaculation is a problem of men of all ages. This global prevalence of this problem indicates its high relevance and seriousness. The importance of finding ways to solve this issue is beyond doubt huge and speaks for itself.
Priligy is a well-known drug that helps to deeply solve intimate problems associated with premature ejaculation. Sexual satisfaction is an important indicator of the quality of life. It strongly depends on self-esteem, relationships with others, success in business. Having lost the ability to satisfy a partner, a person experiences a severe stress which further exacerbates the problem. Therefore, premature ejaculation can and should be treated.
The preparation Priligy is used for:
Most men experience a positive effect of using Priligy from the first intake. In some cases, two or more medications are required to overcome premature ejaculation. The action of Priligy is based on the inhibition of the reuptake of serotonin by neurons. The mechanism of ejaculation is mainly regulated by the sympathetic nervous system the fibers of which innervate vas deferens, seminal vesicles, urethra muscles, prostatic gland, and neck of the bladder. This causes a coordinated contraction leading to ejaculation. Bu influencing the described reflex, Priligy significantly increases the latent period. The duration of impulse of motoneurons decreases in this case. Being essentially a selective inhibitor of serotonin reuptake, the drug reduces the degree of anxiety, tension, and stress. But unlike other antidepressants, dapoxetine is very quickly absorbed and cleared from the body. Such speed, on the one hand, makes it possible to use it for the treatment of premature ejaculation. On the other hand, the agent cannot have long-term efficacy as an antidepressant.
The recommended initial dose for all men is 30 mg; this dose is taken 1-3 hours before planned sexual intercourse. With insufficient effect and good tolerability of 30 mg dose, it can be increased to 60 mg. The maximum recommended dose frequency is 1 time every 24 hours. The doctor prescribing Priligy drug for the treatment of premature ejaculation should assess the risk and benefit of using the drug after the first 4 weeks of treatment or after taking 6 doses, and should determine the risk-benefit ratio for deciding whether to continue treatment with Priligy or not.
For patients with mild or moderate renal impairment, dose adjustment is not required, but caution is advisable. Priligy is not recommended for patients with severe renal dysfunction.
For patients with a weak impairment of liver function, dose adjustment is not required. The drug Priligy is contraindicated to patients with a moderate and severe impairment of hepatic function.
Caution should be taken when increasing the dose of Priligy to 60 mg in individuals with low CYP2D6 activity or in patients who are taking Priligy with active CYP2D6 inhibitors.
Simultaneous intake of active inhibitors of CYP3A4 is contraindicated. Combination of Priligy with moderately active inhibitors CYP3A4 requires the dose decrease of the preparation to 30 mg.
Tablets Priligy are taken 1-3 hours prior to sexual intercourse. The maximum daily dose is 1 pill. The drug must be administered with water. The time of meals and the amount and caloric value of food does not matter. However, the manufacturer warns that rich meal or dinner can delay the occurrence of the effect. The duration of action of dapoxetine is generally 12 hours. It is not recommended misusing alcoholic and low alcohol drinks during the intake. Experts also do not advise drinking grapefruit or orange juice.
Doctors prohibit taking Priligy if a body is dehydrated. For example, it is necessary to refuse temporarily Priligy after intensive sports trainings or sauna. It is desirable drinking water in the last few hours before administration. Do not take medicine if there is a fever or a feeling of onset of the disease. This instruction will help avoid side-effects. Initial dosage of Priligy is 30mg. This amount of active ingredient dapoxetine is sufficient for the vast majority of men. If this dose does not lead to the expected result, it can be increased. The maximum dosage of Priligy is 60mg. The study of a possible overdose has not yet been conducted. However, doctors warn that increasing the admissible amount of Dapoxetine per day can lead to serious side-effects or even be dangerous to health.
The drug Priligy is not intended for use by women.
Based on the limited amount of data obtained during clinical studies, there is no reason to assume that taking dapoxetine by a man can affect a partner’s pregnancy. Well-controlled studies of dapoxetine in pregnant women have not been conducted.
It is not known whether dapoxetine and its metabolites are excreted in breast milk.
Priligy should not be taken by patients younger than 18 years of age.
A single dose of 60 mg dose of dapoxetine did not reveal any significant difference in pharmacokinetics (Cmax, AUC0, Tmax) in healthy elderly men (over 65 years) and men of younger age. The mean values of AUC of dapoxetine and the final elimination half-life were higher by 12% and 46% in elderly men, respectively, compared to men of younger age, respectively.
In patients who received both SSRIs and MAO inhibitor, serious and sometimes fatal reactions were described, including hyperthermia, stiffness, myoclonus, instability of the vegetative system with possible rapid fluctuations in the indices of vital functions, as well as changes in the mental state, including strong agitation, progressing to delirium and coma.
Thioridazine prolongs the QTc interval, which is accompanied by ventricular arrhythmia. Preparations such as Priligy inhibit the enzyme CYP2D6 and seem to inhibit the metabolism of thioridazine. It is expected that the resulting increase in the level of thioridazine will increase the elongation of the QTc interval. The drug Priligy cannot be taken simultaneously with thioridazine and within 14 days after discontinuation of its administration. Similarly, thioridazine cannot be taken within 7 days after discontinuation of Priligy.
As with SSRIs, taking Priligy along with serotonergic drugs (including MAO inhibitors, L-tryptophan, triptanes, tramadol, linezolid, SSRIs, serotonin and norepinephrine seizure inhibitors, lithium and St. John’s Wort may increase the incidence of serotonergic side-effects. Priligy cannot be taken simultaneously with other SSRIs, MAO inhibitors and other serotonergic drugs and within 14 days after discontinuation of these medications.
The intake of Priligy with the drugs acting on central nervous system has not been studied. It is recommended to be cautious when it is necessary to take these drugs at the same time.
Admission ketoconazole 200 mg twice daily for 7 days increased Cmax and AUC0 of dapoxetine (60 mg once) by 35% and 99%, respectively. This increase in Cmax and AUC of the active fraction can be significantly more pronounced in the subpopulation of patients who do not have a functionally active CYP2D6 enzyme, as well as simultaneous administration of active inhibitors of CYP2D6. Priligy should not be taken along with active inhibitors of CYP3A4, for example, ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir and atazanavir.
In clinical trials, the side-effects were noted that were observed frequently and were dose-dependent: nausea (11% and 22 % with 30 mg and 60 mg of dapoxetine, respectively), dizziness (5 % and 10%), headache (5% and 8%), diarrhea (3% and 6%), insomnia (2% and 3%), and fatigue (2% and 4%). The most frequent phenomena requiring withdrawal of treatment were nausea (2% of patients) and dizziness (1%).
The recommended initial dose for all men is 30 mg; this dose is taken 1-3 hours prior to expected increased to 60 mg. The maximum recommended dose frequency is 1 time every 24 hours. A doctor prescribing Priligy for the treatment of premature ejaculation should assess the risk and benefit of using the drug after the first 4 weeks of treatment or after taking 6 doses to avoid overdose and should determine the risk-benefit ratio for deciding whether to continue treatment with Priligy or not. For patients with mild or moderate renal impairment, dose adjustment is not required, but caution is advisable. Priligy is not recommended for patients with severe renal dysfunction. For patients with a weak impairment of liver function, dose adjustment is not required. Priligy is contraindicated to patients with a moderate and severe impairment of liver function. Simultaneous administration of active inhibitors of CYP3A4 is contraindicated. With the simultaneous use of Priligy with moderately active inhibitors of CYP3A4, the dose of the drug should be reduced to 30 mg.
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It is recommended to start with 30 mg for an insufficient effect and raise it to 60 mg if the initial dose did not cause undesirable side-effects. 60 mg is maximum that can be used per day, if it does not lead to proper results, you should refuse the treatment with Priligy.
Studies show that alcohol and dapoxetine do not cause direct interaction. This means that you can take them together, and this will not lead to serious side-effects. However, dapoxetine can enhance the side-effects of alcohol. Large doses of alcohol can lead to undesirable effects, reduce erection, endurance, coordination, thus eliminating the possibility of achieving the expected results.
There is a widespread opinion that a course of taking this remedy is necessary for better results. This opinion is most likely due to other SSRIs (the kind of antidepressants) such as fluoxetine and paroxetine, which were not officially used as a means to prolong sex, and had a cumulative effect. In fact, there is no evidence that Priligy should be used within the therapeutic course. What distinguishes it from drugs with a similar mechanism of action taken as antidepressants is the absorption induction period. It quickly begins to act and is rapidly cleared from the body, so it has no cumulative effect, and will not save you from premature ejaculation in the long term. Used only if necessary, the dose works on average up to 12 hours.
The conducted studies indicate the high safety of the drug, however this medicine has not yet been fully investigated, and there is insufficient experience of using to accurately confirm whether Priligy is harmful. It is known that antidepressants with prolonged applicaiton can reduce libido, and although dapoxetine has a short-term effect without the accumulation of substance in the body, such fears occur.
In addition to chemically synthesis in the process of 6 stages of the active component dapoxetine, the formulation of the tablets includes auxiliary substances for shaping, color, faster absorption, etc.
This is not a prohibited remedy and does not apply to narcotics. Dapoxetine is currently approved for use in at least 50 countries.
The causes of erectile dysfunction are usually physical, and the causes of premature ejaculation are psychological, so the therapeutic approach to these problems is completely different. But, if problems with erection arise as a result of psychological factors, in particular fear or anxiety before intercourse, it is quite possible that dapoxetine will help in this case.
There are no contraindications for combining dapoxetine with PDE5 inhibitors, such as Viagra, Levitra, Cialis, but each of them has its own list of side-effects, so the risks of their manifestation are increased. Potential pharmacokinetic interactions between dapoxetine and PDE5 inhibitors (drugs for potency) were studied in a study in which 24 men participated. Subjects combined dapoxetine 60 mg with Viagra (sildenafil) 100 mg and dapoxetine 60 mg with Cialis (tadalafil) 20 mg. Most side-effects were mild. As a result, it became known that dapoxetine does not have clinically significant pharmacokinetic interactions with tadalafil or sildenafil, and the combinations are well tolerated.